Prudently conduct the engineering and synthesis of the SARS-CoV-2 virus
Identifieur interne : 000243 ( Main/Exploration ); précédent : 000242; suivant : 000244Prudently conduct the engineering and synthesis of the SARS-CoV-2 virus
Auteurs : Peng Gao [République populaire de Chine] ; Shiwen Ma [République populaire de Chine] ; Daru Lu [République populaire de Chine] ; Carl Mitcham [République populaire de Chine, États-Unis] ; Yijia Jing [République populaire de Chine] ; Guoyu Wang [République populaire de Chine]Source :
- Synthetic and Systems Biotechnology [ 2405-805X ] ; 2020.
Abstract
In response to the outbreak of COVID-19 that has been sweeping the world, scientists reconstructed the SARS-CoV-2 rapidly using a synthetic genomics platform, in order to accelerate therapeutics and vaccine development. However, given the dual-use nature of this technology, there exists a high biosecurity risk. This paper points out the potential risks of the engineering SARS-CoV-2 virus and puts forward 6 questions to this work. The authors emphasize that the two basic values of safety/security and intellectual freedom of research must be considered evenly. From the perspective of responsible development of biotechnology, this paper calls for a careful assessment to the risks of the technology, replacing risky technologies with safe ones. The risks of publication also need to be strictly assessed. The authors believe, in addition to enhancing the “self-government” and self-discipline of scientists and scientific communities, government supervision must be reinforced, laws and regulations should be improved, and global regulation framework ought to be constructed.
Url:
DOI: 10.1016/j.synbio.2020.03.002
PubMed: NONE
PubMed Central: 7178320
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000825
- to stream Pmc, to step Curation: 000825
- to stream Pmc, to step Checkpoint: 000196
- to stream Ncbi, to step Merge: 001408
- to stream Ncbi, to step Curation: 001408
- to stream Ncbi, to step Checkpoint: 001408
- to stream Main, to step Merge: 000243
- to stream Main, to step Curation: 000243
Le document en format XML
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xml:lang="en" level="a" type="main">Prudently conduct the engineering and synthesis of the SARS-CoV-2 virus</title><author><name sortKey="Gao, Peng" sort="Gao, Peng" uniqKey="Gao P" first="Peng" last="Gao">Peng Gao</name><affiliation wicri:level="1"><nlm:aff id="aff1">The Human Phenome Institute, Fudan University, Shanghai, 200433, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Human Phenome Institute, Fudan University, Shanghai, 200433</wicri:regionArea><wicri:noRegion>200433</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Law School, Anhui University of Finance and Economics, Bengbu, Anhui, 233030, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Law School, Anhui University of Finance and Economics, Bengbu, Anhui, 233030</wicri:regionArea><wicri:noRegion>233030</wicri:noRegion></affiliation></author><author><name sortKey="Ma, Shiwen" sort="Ma, Shiwen" uniqKey="Ma S" first="Shiwen" last="Ma">Shiwen Ma</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Philosophy, Dalian University of Technology, Dalian, Liaoning, 116024, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Philosophy, Dalian University of Technology, Dalian, Liaoning, 116024</wicri:regionArea><wicri:noRegion>116024</wicri:noRegion></affiliation></author><author><name sortKey="Lu, Daru" sort="Lu, Daru" uniqKey="Lu D" first="Daru" last="Lu">Daru Lu</name><affiliation wicri:level="1"><nlm:aff id="aff4">State Key Laboratory of Genetic Engineering and MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, 200433, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Genetic Engineering and MOE Engineering Research Center of Gene Technology, School of Life Sciences, Fudan University, Shanghai, 200433</wicri:regionArea><wicri:noRegion>200433</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Key Laboratory of Birth Defects and Reproductive Health of National Health Commission, Chongqing Population and Family Planning, Science and Technology Research Institute, Chongqing, 400020, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Birth Defects and Reproductive Health of National Health Commission, Chongqing Population and Family Planning, Science and Technology Research Institute, Chongqing, 400020</wicri:regionArea><wicri:noRegion>400020</wicri:noRegion></affiliation></author><author><name sortKey="Mitcham, Carl" sort="Mitcham, Carl" uniqKey="Mitcham C" first="Carl" last="Mitcham">Carl Mitcham</name><affiliation wicri:level="1"><nlm:aff id="aff6">Renmin University of China, Beijing, 100872, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Renmin University of China, Beijing, 100872</wicri:regionArea><wicri:noRegion>100872</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Colorado School of Mines, Golden, Colorado, 80401, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Colorado School of Mines, Golden, Colorado, 80401</wicri:regionArea><wicri:noRegion>80401</wicri:noRegion></affiliation></author><author><name sortKey="Jing, Yijia" sort="Jing, Yijia" uniqKey="Jing Y" first="Yijia" last="Jing">Yijia Jing</name><affiliation wicri:level="1"><nlm:aff id="aff8">Institute for Global Public Policy & School of International Relations and Public Affairs, Fudan University, Shanghai, 200433, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute for Global Public Policy & School of International Relations and Public Affairs, Fudan University, Shanghai, 200433</wicri:regionArea><wicri:noRegion>200433</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Guoyu" sort="Wang, Guoyu" uniqKey="Wang G" first="Guoyu" last="Wang">Guoyu Wang</name><affiliation wicri:level="1"><nlm:aff id="aff9">School of Philosophy, Fudan University, Shanghai, 200433, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Philosophy, Fudan University, Shanghai, 200433</wicri:regionArea><wicri:noRegion>200433</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff10">Center for Biomedical Ethics, Fudan University, Shanghai, 200433, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Biomedical Ethics, Fudan University, Shanghai, 200433</wicri:regionArea><wicri:noRegion>200433</wicri:noRegion></affiliation></author></analytic><series><title level="j">Synthetic and Systems Biotechnology</title><idno type="eISSN">2405-805X</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In response to the outbreak of COVID-19 that has been sweeping the world, scientists reconstructed the SARS-CoV-2 rapidly using a synthetic genomics platform, in order to accelerate therapeutics and vaccine development. However, given the dual-use nature of this technology, there exists a high biosecurity risk. This paper points out the potential risks of the engineering SARS-CoV-2 virus and puts forward 6 questions to this work. The authors emphasize that the two basic values of safety/security and intellectual freedom of research must be considered evenly. From the perspective of responsible development of biotechnology, this paper calls for a careful assessment to the risks of the technology, replacing risky technologies with safe ones. The risks of publication also need to be strictly assessed. The authors believe, in addition to enhancing the “self-government” and self-discipline of scientists and scientific communities, government supervision must be reinforced, laws and regulations should be improved, and global regulation framework ought to be constructed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thao, T T N" uniqKey="Thao T">T.T.N. Thao</name></author><author><name sortKey="Labroussaa, F" uniqKey="Labroussaa F">F. Labroussaa</name></author><author><name sortKey="Ebert, N" uniqKey="Ebert N">N. Ebert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baillie, L" uniqKey="Baillie L">L. Baillie</name></author><author><name sortKey="Dyson, H" uniqKey="Dyson H">H. Dyson</name></author><author><name sortKey="Simpson, A" uniqKey="Simpson A">A. Simpson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, S" uniqKey="Miller S">S. Miller</name></author><author><name sortKey="Selgelid, M J" uniqKey="Selgelid M">M.J. Selgelid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuller, L L" uniqKey="Fuller L">L.L. Fuller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Enserink, M" uniqKey="Enserink M">M. Enserink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White House" uniqKey="White House">White House</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Regalado, A" uniqKey="Regalado A">A. Regalado</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Engineering And Physical Sciences Research Council" uniqKey="Engineering And Physical Sciences Research Council">Engineering and Physical Sciences Research Council</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Gao, Peng" sort="Gao, Peng" uniqKey="Gao P" first="Peng" last="Gao">Peng Gao</name></noRegion><name sortKey="Gao, Peng" sort="Gao, Peng" uniqKey="Gao P" first="Peng" last="Gao">Peng Gao</name><name sortKey="Jing, Yijia" sort="Jing, Yijia" uniqKey="Jing Y" first="Yijia" last="Jing">Yijia Jing</name><name sortKey="Lu, Daru" sort="Lu, Daru" uniqKey="Lu D" first="Daru" last="Lu">Daru Lu</name><name sortKey="Lu, Daru" sort="Lu, Daru" uniqKey="Lu D" first="Daru" last="Lu">Daru Lu</name><name sortKey="Ma, Shiwen" sort="Ma, Shiwen" uniqKey="Ma S" first="Shiwen" last="Ma">Shiwen Ma</name><name sortKey="Mitcham, Carl" sort="Mitcham, Carl" uniqKey="Mitcham C" first="Carl" last="Mitcham">Carl Mitcham</name><name sortKey="Wang, Guoyu" sort="Wang, Guoyu" uniqKey="Wang G" first="Guoyu" last="Wang">Guoyu Wang</name><name sortKey="Wang, Guoyu" sort="Wang, Guoyu" uniqKey="Wang G" first="Guoyu" last="Wang">Guoyu Wang</name></country><country name="États-Unis"><noRegion><name sortKey="Mitcham, Carl" sort="Mitcham, Carl" uniqKey="Mitcham C" first="Carl" last="Mitcham">Carl Mitcham</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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